Description
Gluconolactone is an active ingredient that gently treats the skin without affecting the deeper layers. The effect is very similar to that of AHAs (fruit acids like glycolic or lactic acid), but as a type of polyhydroxy acid, gluconolactone is more beneficial. As it contains five hydroxyl groups, it has more moisturizing properties compared to alpha hydroxy acid with only one hydroxyl group.
Because it is a larger molecule (with a three-dimensional molecule of 178 Da), gluconolactone penetrates the skin slowly, without burning it, as other chemical peels do with alternative active ingredients. That’s why non-irritating gluconolactone is perfect even for dry and hypersensitive skin. It also activates lipid synthesis in keratinocytes, providing moisture to the stratum corneum of the skin. Gluconolactone has the ability to transfer water molecules, playing a central role in skin hydration. As a chelating agent, gluconolactone has the ability to bind and remove free radicals from the body.
The oxidation process, caused by an overabundance of iron and the influence of ultraviolet rays, occurs in skin pigmentation, a typical sign of photoaging. Gluconolactone helps bind free iron ions, preventing the oxidation process and the consequences of ultraviolet radiation. Gluconolactone initiates processes that precede hyaluronic acid production in keratinocytes and fibroblasts, as well as matrix metalloproteinase and collagen synthesis.
Properties
Properties: The interaction of gluconolactone with the skin begins as soon as it is applied, affecting the acid mantle, restoring the proper pH. Recovery of skin barrier integrity depends on serine protease activity, which means that the reduction in serine protease activity caused by lower pH levels in the acid mantle can help maintain cell junctions. Anti-inflammatory and antioxidant effects, stimulate the skin’s immune system. Gluconolactone is a natural antioxidant as effective as vitamin C and vitamin E.
Gluconolactone blocks the synthesis of pro-interleukin-1, which can cause increased inflammation. The interaction of gluconolactone with the skin begins as soon as it is applied, affecting the acid mantle, restoring the proper pH. Recovery of skin barrier integrity depends on serine protease activity, which means that the reduction in serine protease activity caused by lower pH levels in the acid mantle can help maintain cell junctions.
It also activates lipid synthesis in keratinocytes, providing moisture to the stratum corneum of the skin. Gluconolactone has the ability to transfer water molecules, playing a central role in skin hydration. As a chelating agent, gluconolactone has the ability to bind and remove free radicals from the body.
The oxidation process, caused by an overabundance of iron and the influence of ultraviolet rays, occurs in skin pigmentation, a typical sign of photoaging. Gluconolactone helps bind free iron ions, preventing the oxidation process and the consequences of ultraviolet radiation.
Benefits
Dead skin cells are gently removed, causing no skin irritation. Gluconolactone is used for inflammatory skin diseases accompanied by hyperkeratosis: psoriasis, acne, dermatitis, anti-aging as a means of preventing and correcting age changes of the skin, especially sensitive ones. Due to the absence of irritating action, it does not require neutralization, it can be carried out often enough to achieve a noticeable effect.
Improves skin hydration, softens expression lines and wrinkles, increases skin elasticity, evens out skin tone due to keratolytic action, removes roughness and tightens pores. Gluconolactone does not cause irritation or sensitization of the skin and mucous membranes.
Indications
indications: epidermal dehydration, acne, comedones, blackheads, pimples, acne, post-acne, epidermal hyperpigmentation (spots on the outer layer of the skin), hyperkeratosis, seborrhea, enlarged pores, loose and saggy skin, dull and uneven skin tone, photoaging (caused by excessive ultraviolet radiation).
Precautions: For external use only.
Do not apply to broken or peeling skin. Immediately wash with water and discontinue use if excessive redness or irritation occurs.
Keep out of the reach of children.
Contraindications
Contraindications: pregnancy and lactation, herpes, warts, secondary infection, small scratch marks on the skin, skin hypersensitivity, oncological diseases, eczema, psoriasis, sunburned skin
Detailed Descripcion
Gluconolactone Peel 25%
Gentle Renewal, Deep Hydration & Skin Barrier Protection
The Gluconolactone Peel 25% is a professional chemical peel belonging to the PHA – Poly Hydroxy Acids family, developed to promote progressive skin renewal, deep hydration and improvement of skin quality, making it especially suitable for sensitive, reactive, dehydrated and irritation-prone skin.
Gluconolactone stands out for its high skin tolerance and its ability to gently exfoliate while helping preserve hydration and the integrity of the skin barrier.
Scientific Characteristics
✔ Main Acid
✔ Concentration
✔ Category
✔ Peel Depth
- Very superficial to superficial
✔ Main Cosmetic Focus
- Sensitive skin, hydration & gentle renewal
✔ Main Action
- Hydrating and antioxidant exfoliation
What is Gluconolactone?
Gluconolactone is a Poly Hydroxy Acid (PHA) recognized in modern aesthetic medicine for its ability to:
✔ promote gentle exfoliation
✔ improve skin hydration
✔ protect the skin barrier
✔ reduce skin sensitivity
✔ provide antioxidant action
Compared to traditional AHAs, Gluconolactone has larger molecules, resulting in slower and more controlled penetration, making it ideal for:
- sensitive skin
- reactive skin
- mild rosacea
- dehydrated skin
- mild photoaging
- delicate glow protocols
In addition to epidermal renewal, it also helps minimize transepidermal water loss and improve skin comfort.
How does it work on the skin?
Gluconolactone Peel 25% works through progressive and extremely gentle chemical exfoliation of the superficial layers of the skin.
Its action helps to:
- remove accumulated dead skin cells
- improve skin hydration
- strengthen the skin barrier
- improve superficial texture
- increase skin radiance
- progressively revitalize the skin
👉 The result is skin that appears:
✨ more hydrated
✨ brighter
✨ more comfortable
✨ with refined texture
✨ healthy and revitalized-looking
Importance of pH and Progressive Exfoliation
The effectiveness of a PHA peel depends on the balance between:
- concentration
- pH
- penetration speed
- skin hydration
- skin tolerance
Gluconolactone allows:
✔ extremely controlled exfoliation
✔ progressive renewal
✔ lower risk of irritation
✔ excellent skin comfort
✔ safety for sensitive skin
In modern aesthetic medicine, PHAs are considered essential for protocols focused on skin recovery and strengthening.
Main Benefits of Gluconolactone Peel 25%
✨ Deep skin hydration
✨ Gentle skin renewal
✨ Strengthening of the skin barrier
✨ Enhanced skin radiance
✨ Reduction of skin sensitivity
✨ Skin texture refinement
✨ More comfortable and balanced skin
✨ Progressive antioxidant action
Aesthetic Indications
Gluconolactone Peel 25% can be integrated into professional protocols for:
✔ Sensitive skin
✔ Reactive skin
✔ Dehydrated skin
✔ Mild rosacea
✔ Mild photoaging
✔ Uneven texture
✔ Lack of radiance
✔ Hydrating skin renewal
Type of Exfoliation
Gluconolactone Peel 25% provides:
👉 Very superficial, hydrating and antioxidant exfoliation
This allows:
✔ excellent skin tolerance
✔ quick recovery
✔ use on sensitive skin
✔ safe and progressive protocols
✔ combination with multiple aesthetic treatments
Expected Results
With appropriate and progressive protocols, it is possible to observe:
- more hydrated skin
- improved radiance
- greater skin comfort
- refined texture
- more balanced skin
- healthy and revitalized appearance
Since skin renewal is a cumulative biological process, results become progressively more visible throughout the treatment sessions.
Can it be combined with other treatments?
Yes.
Gluconolactone Peel 25% is extremely versatile in combined protocols for sensitive skin and skin revitalization.
It can be combined with:
✔ hydrating mesotherapies
✔ hyaluronic acid
✔ antioxidant vitamins
✔ regenerative LED therapy
✔ gentle radiofrequency
✔ glow protocols
✔ gentle anti-aging treatments
👉 Example:
Sensitive Skin Glow Protocol
1️⃣ Gluconolactone Peel 25%
2️⃣ Hydrating mesotherapy with hyaluronic acid
3️⃣ Regenerative LED therapy
👉 Result:
- more hydrated skin
- healthy radiance
- greater skin comfort
- refined texture
- revitalized appearance
mesoInstitute / TherapDerma Philosophy
mesoInstitute peels were developed following a scientific approach based on:
✔ progressive exfoliation
✔ respect for the skin barrier
✔ balanced hydration
✔ skin comfort
✔ natural and visible results
Modern aesthetic medicine seeks:
👉 gentle and effective renewal
👉 maximum safety
👉 overall improvement of skin quality
👉 personalized protocols
👉 sustainable and natural results.
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