MURAXIN – Product description
INCOBOTULINUMTOXINA Type A
Trademarketed by Therapmedic LLC is produced in Spain
STRENGTH (BTX-A: PRODUCT): 01:01
Intended use: Cosmetic Use including Glabellar lines (Frontals, Orbiculars of the eyelids,
Corrugators, Procerus, Platismal Bands, Orbicular of the lips)
Mode of action: SNAP-25
Pharmaceutical form: Powder to be diluted in 1,5ml saline solution (0,9% NaCl)
Excipients: Human serum albumin, sucrose
Storage before Dilution: Freezer (-8 to -17 degrees Celcius)
Storage after dilution: Fridge (up to 3 months at 2-6 degrees celsius)
Transportation: can hold up to 20 days without any cold
First results shown after: 2 hours
Full results after: 2 days
Effect lasting: 3 to 4 months depending on the patient’s lifestyle
MURAXIN – Product details
Botulinum toxin is a neurotoxin, that is, it alters the function of the nervous system, the
communication between nerves and muscles.
The botulinum toxin that we use in our consultations has been refined and purified previously,
and is applied in minimum doses and only in the muscle that we want to relax. These amounts
are so small that there is no risk.
Botulinum Toxin was used for medical purposes for the first time in the late 1980s for the
treatment of spasms or tics of the eyelids and for strabismus or crossed eyes. The latter occurs
because one of the six small muscles that move the eye is weaker. The Botulinum Toxin is used
to relax the opposite muscle, obtaining as a result that the eye is aligned.
In the eighties, Jean Carruthers, an ophthalmologist who works in Vancouver (Canada),
commented to her husband Alastair Carruthers, dermatologist, that when he used Botulinum
Toxin to improve the strabismus of his patients, frown lines softened. As a result of this
observation, he carried out a study with the staff of the clinic and in themselves using Botox to
minimize wrinkles of expression between the eyebrows. For this finding, the Carruthers couple
is considered as the parents of the most important discovery of the last decades in aesthetic
dermatology: the use of botulinum toxin to rejuvenate.
Since then, dermatologists and plastic surgeons around the world began using botulinum toxin
to relax the muscles that produced wrinkles of expression. In the year 2000, more than one
million people had been treated with Botox. In 2002 the FDA approved its aesthetic use in the
United States, and in Spain it was approved in 2004.
Botulinum Toxin prevents the nerve from communicating to the muscle that it must contract.
Once the Botulinum Toxin is injected into the muscle, it is located in the nerve endings that
innervate it, that is, in the fibers that “order” it when to contract. This order is produced
through a neurotransmitter called acetylcholine. Botulinum Toxin prevents the release of
acetylcholine, thus preventing muscle contraction. Therefore, the muscle remains at rest.
Botulinum Toxin only prevents the nerve from transmitting to the muscle that must contract.
For a muscle to contract it needs a signal. It originates in the brain and down through the
spinal cord to the nerves, which end in the muscle. The Botulinum Toxin prevents
communication between the nerve and the muscle.
Acetylcholine: is a neurotransmitter that is also found in the nerve fibers that go to the sweat
glands, and its presence makes these glands synthesize it. Therefore, when injecting Botox in
an area with many sweat glands, such as the armpit or hands, the area immediately stops
sweating. Botulinum Toxin has become a wonderful treatment for hyperhidrosis (excessive
The effects of Botulinum Toxin are temporary. After the injection of Botulinum Toxin, the
nerves that are under its action begin to branch out to create new unions between them and
the muscle. This “reconnection” can take several weeks, until in 3 months the muscle begins to
receive new orders to contract.
Basically there are two types of wrinkles. The dynamic wrinkles or expression are those that
are formed when gesturing, and are located primarily around the eyes and mouth. On the
other hand are static wrinkles, which do not change just with the different expressions of the
face, and are mainly wrinkles or furrows that go from the nose to the corners of the mouth
(nasogenian grooves) and those that go from the corners of the mouth to the chin (puppet
Muraxin is the most advanced product for wrinkles treatment, the also known Dynamic
Wrinkles (the ones one does with expressions).
Dynamic wrinkles are produced by muscle contraction (frown, crow's feet, forehead wrinkles,
etc.), while static wrinkles are formed by the insertion of certain muscles in the skin.
Therefore, the dynamics only appear when gesturing and the static ones with the face at rest.
Recently, a study has been presented at the American Academy of Dermatology of two twin
sisters, one of whom had been wearing Botulinum Toxin for eight years and the other had
never worn it. The results were amazing. The one that had been injected Botulinum Toxin had
not only much less wrinkles of expression, but also had less static wrinkles, and even
eyebrows, nose, mouth, neck, etc. they were “higher”. This demonstrates the preventive role
of Botulinum Toxin on facial aging.
Although Botulinum Toxin is safe for most patients, its safety has not been demonstrated in
pregnant women or those who are breastfeeding. It is also not advisable to inject it in people
suffering from a neurological disease, since the Botulinum Toxin acts on the nerve endings of
Some patients tell us that the effects of Botulinum Toxin last them very little time, and others,
however, comment that they last even more than 8 months. What does it depend on? The
explanation lies in the anatomy of the patient, in his musculature. In general terms Muraxin
lasts 3 to 4 months.
According to the classification of Brazilian plastic surgeon Mauricio de Maio, patients can be
■ Kinetics: patients who move their muscles when they want. There is a close relationship
between emotions and gestures. In these cases the effect lasts between 6 and 9 months
■ Hyperkinetics: patients who move their muscles without wanting to. There is no relationship
between emotions and gestures, that is, sometimes they frown spontaneously. The effect of
Botox in these cases is 3 to 5 months.
■ Hypertonic: patients who move their muscles constantly, that is, they always have a degree
of contraction in the forehead, crow's feet, etc. In these cases, the Botox lasts less than 2